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Publications and Studies
2022
Symonds EL, Pedersen SK, Yeo B, Al Naji H, Byrne SE, Roy A, Young GP. Assessment of tumor burden and response to therapy in patients with colorectal cancer using a quantitative ctDNA test for methylated BCAT1/IKZF1. Mol Oncol. 2022 Jan 9. doi: 10.1002/1878-0261.13178. Epub ahead of print. PMID: 35000264
2021
Young GP, Symonds EL, Nielsen HJ, Ferm L, Christensen IJ, Dekker E, van der Vlugt M, Mallant-Hent RC, Boulter N, Yu B, Chan M, Tevz G, LaPointe LC, Pedersen SK. Evaluation of a panel of tumor-specific differentially-methylated DNA regions in IRF4, IKZF1 and BCAT1 for blood-based detection of colorectal cancer. Clin Epigenetics. 2021 Jan 21;13(1):14. doi: 10.1186/s13148-020-00999-y. PMID: 33478584; PMCID: PMC7818774
2020
Musher et al. Evaluation of Circulating Tumor DNA for Methylated BCAT1 and IKZF1 to Detect Recurrence of Stage II/ Stage III Colorectal Cancer. Cancer Epidemiology, Biomarkers & Prevention. September 2020
Symonds et al. Circulating epigenetic biomarkers for detection of recurrent colorectal cancer. Cancer. January 2020 2019
Symonds et al. A randomised controlled trial testing provision of fecal and blood test options on participation for colorectal cancer screening. Cancer Prevention Research. 2 July 2019
2018
Saluja et al. The Use of Circulating Tumor DNA for Prognosis of Gastrointestinal Cancers. Frontiers in Oncology. 24 July 2018
Murray et al. Relationship between post-surgery detection of methylated circulating tumor DNA with risk of residual disease and recurrence-free survival. Journal of Cancer Research and Clinical Oncology. 10 July 2018 Symonds et al. Circulating tumour DNA for monitoring colorectal cancer—a prospective cohort study to assess relationship to tissue methylation, cancer characteristics and surgical resection. Clinical Epigenetics. 16 May 2018 Jedi et al. Methylation and Gene Expression of BCAT1 and IKZF1 in Colorectal Cancer Tissues. Clinical Medicine Insights: Oncology. 10 May 2018 2017
Shapiro et al. A Comparison of Fecal Immunochemical and High-Sensitivity Guaiac Tests for Colorectal Cancer Screening. Am J Gastroenterol advance online publication. 10 October 2017; doi: 10.1038/ajg.2017.285
Murray et al. Validation of a Circulating Tumor-Derived DNA Blood Test for Detection of Methylated BCAT1 and IKZF1 DNA. JALM. 2017, doi: 10.1373/jalm.2017.023135 2016
Mitchell et al. Evaluation of Methylation Biomarkers for Detection of Circulating Tumor DNA and Application to Colorectal Cancer. Genes. 2016, 7(12), 125; doi:10.3390/genes7120125
Young et al. A Cross-sectional Study Comparing a Blood Test for Methylated BCAT1 and IKZF1 Tumor-derived DNA with CEA for Detection of Recurrent Colorectal Cancer. Cancer Medicine. doi:10.1002/cam4.868 Symonds et al. A Blood Test for Methylated BCAT1 and IKZF1 vs. a Fecal Immunochemical Test for Detection of Colorectal Neoplasia. Clin Trans Gastro. 2016; 7, e137 2015
Pedersen et al. A Two-Gene Blood Test for Methylated DNA Sensitive for Colorectal Cancer. PLoS One. 2015;10(4):e0125041
Symonds et al. Improving Participation in Colorectal Cancer Screening: a Randomised Controlled Trial of Sequential Offers of Fecal then Blood Based Non-Invasive Tests. Asian Pac J Cancer. Prev, 16 (18), 8455-8460 Pedersen et al. Evaluation of an Assay for Methylated BCAT1 and IKZF1 in Plasma for Detection of Colorectal Neoplasia. BMC CANCER. 15(1):654. October 2015 2014
Mitchell et al. A Panel of Genes Methylated with High Frequency in Colorectal Cancer. BMC Cancer. 2014;14:54
Pedersen et al. CAHM, a Long Non-Coding RNA Gene Hypermethylated in Colorectal Neoplasia. Epigenetics. 2014 Aug;9(8):1071-82 2012
LaPointe et al. Discovery and Validation of Molecular Biomarkers for Colorectal Adenomas and Cancer with Application to Blood Testing. PLoS One. 2012;7(1):e29059
Collins et al. Screening for Colorectal Cancer and Advanced Colorectal Neoplasia in Kidney Transplant Recipients: Cross Sectional Prevalence and Diagnostic Accuracy Study of Fecal Immunochemical Testing for Hemoglobin and Colonoscopy. BMJ. 2012 Jul 25;345:e4657 2011
Graham et al. Colorectal Neoplasia Differentially Expressed (CRNDE), a Novel Gene with Elevated Expression in Colorectal Adenomas and Adenocarcinomas. Genes Cancer. 2011 Aug;2(8):829-40
2008
LaPointe et al. Map of Differential Transcript Expression in the Normal Human Large Intestine. Physiol Genomics. 2008 Mar 14;33(1):50-64
2006
Smith et al. Comparison of a Brush-Sampling Fecal Immunochemical Test for Hemoglobin with a Sensitive Guaiac-Based Fecal Occult Blood Test in Detection of Colorectal Neoplasia. Cancer. 2006 Nov 1;107(9):2152-9
2003
Cole et al. A Randomised Trial of the Impact of New Fecal Hemoglobin Test Technologies on Population Participation in Screening for Colorectal Cancer. J Med Screen. 2003;10(3):117-22
Young et al. Prescreening Evaluation of a Brush-Based Fecal Immunochemical Test for Hemoglobin. J Med Screen. 2003;10(3):123-8 |
Abstracts & Posters
2019
Pedersen et al. Performance Evaluation of a Blood Test Assaying for ctDNA Methylated in IRF4, BCAT1, IKZF1 for Detection of Colorectal Cancer. UEGW Week October 2019.
Symonds et al. Performance Comparison of the Methylated BCAT1/IKZF1 ctDNA Test (Colvera) with the CEA Assay for Detection of Recurrent Colorectal Cancer. ASCO Annual Meeting. June 3 2019 2018
Symonds et al. Specificity of methylated BCAT1 and IKZF1 for colorectal cancer. ASCO GI. 2018
Young et al. Methylated circulating tumor-derived DNA for detection of colorectal cancer – relationship of methylated BCAT1 or IKZF1 to tissue expression and comparison with FIT. Early Detection Research Network Annual Meeting. 2018 Symonds et al. Circulating Tumor DNA to Assess Characteristics of Colorectal Cancer and Completeness of Surgical Resection. Digestive Disease Week Annual Meeting. 2018 Detection of ctDNA biomarkers post resection and relationship to recurrent disease in colorectal cancer patients. Online abstract publications at ASCO. 2018 Murray et al. A prospective cohort study in colorectal cancer assessing the relationship between post-surgery detection of methylated BCAT1 or IKZF1 ctDNA and risk for residual disease and survival. ASCO Annual Meeting. 2018 2017
Symonds et al. Predictors of circulating tumor-derived methylated BCAT1 and IKZF1 DNA in colorectal cancer patients. ASCO GI Symposium. 2017
Symonds et al. The relationship between the degree of aberrant methylation in colorectal cancer tissue and appearance of tumor-derived DNA in blood. ASCO GI Symposium. 2017 Symonds et al. Circulating tumor DNA before and after resection for colorectal cancer. ASCO Annual Meeting. 2017 Alsobrook et al. Analytical validation of a circulating tumor methylated-DNA assay for detection of colorectal cancer recurrence. AMP Annual Meeting. 2017 Boulter et al. A droplet digital PCR assay for detection of methylated BCAT1 and IKZF1 in circulating tumor DNA. AMP Annual Meeting. 2017 Murray et al. Effect of blood collection tubes on circulating tumor DNA (ctDNA) yield and specificity. AMP Annual Meeting. 2017 2016
Pedersen et al. A novel 2-gene blood test for colorectal cancer recurrence. ASCO GI Symposium. 2016
Symonds et al. Symonds et al. ASCO GI Symposium. 2016 2015
Baker et al. Detection of variable methylation patterns improves sensitivity of a colorectal cancer blood test. Digestive Disease Week. 2015
Symonds et al. Improving participation rates in community-based colorectal cancer screening – role of a blood test. Digestive Disease Week. 2015 Symonds et al. Methylated BCAT1 and IKZF1 DNA in plasma as novel biomarkers for colorectal cancer recurrence. Digestive Disease Week. 2015 Symonds et al. Comparison of a methylated two-gene (BCAT1-IKZF1) blood test to FIT for detection of colorectal neoplasia. Digestive Disease Week. 2015 Mangira et al. The morphological features of colorectal tumors that are associated with the appearance of methylated DNA in plasma. Digestive Disease Week. 2015 Vol. 10, Issue Suppl. S9, p211-212.. Asia-Pacific Journal of Clinical Oncology. 2015 DOI: 10.1111/ajco.12332 2014
Baker et al. Detection of variable methylation patterns improves colorectal cancer blood test sensitivity. AGW. 2014
Symonds et al. A methylated DNA blood test for colorectal cancer screening returns a lower false positivity rate than a faecal immunochemical test in people with benign bleeding conditions. AGW. 2014 Mangira et al. Appearance of tumor-associated methylated DNA in plasma correlates with colorectal tumour invasion. Flinders Centre for Innovation in Cancer. 2014 Baker et al. Method validation of a laboratory–developed blood test for colorectal cancer. Combio2014 Conference. 2014;11:130281 Young. Evaluation of a 2-gene (IKZF1 and BCAT1) DNA blood test for detection of colorectal cancer. Digestive Disease Week. 2014 Redwood et al. Comparison of Fecal Occult Blood Tests for Colorectal Cancer Screening in an Alaska Native Population With High Prevalence of Helicobacter pylori Infection, 2008-2012. Prev Chronic Dis. 2014;11:130281 Mitchell et al. Colorectal cancer methylation biomarkers. Keystone Symposia Conference. Cancer Epigenetics. 2014 2013
Baker et al. Clinical evaluation of a novel duplexed 2-gene DNA methylation blood test for colorectal cancer. Lorne Genome Conference. 2013
Rand et al. Development of non-bisulphite-based assays for colorectal cancer DNA methylation markers. Gordon Research Conference. Cancer Genetics & Epigenetics. 2013 2012
Pedersen. Novel methylation DNA biomarkers for colorectal neoplasia: From tissue to blood. WEO Colorectal Cancer Screening Committee Meeting. 2012
Pedersen. Discovery and validation of a novel DNA methylation biomarker for colorectal cancer with application to blood testing. Digestive Disease Week. 2012 Baker et al. Clinical Evaluation of a novel 2-gene methylation blood test for colorectal cancer. Australian Gastroenterology Week. 2012 2011
Thomas et al. Plasma Testing of Gene Expression Biomarkers for Colorectal Neoplasia discovered in Neoplastic Colorectal Tissue. Digestive Disease Week (AGA). 2011
2009
Pedersen et al. A novel colorectal neoplasia gene (CRNG) with high sensitivity and specificity for both adenomas and carcinomas. Digestive Disease Week (AGA). 2009
LaPointe et al. Biomarkers with high sensitivity and specificity for colorectal adenomas and carcinomas. Digestive Disease Week (AGA). 2009 Pedersen et al. Alternative splicing of S100A11 in colorectal adenomas and carcinomas. Digestive Disease Week (AGA). 2009 Moynihanet al. Upregulation of mesolthelin, RegIV, and transcobalamin in colon adenomas and cancer. Digestive Disease Week (AGA). 2009 2006
Wilson et al. Associative gene networks from microarray data in the normal colon. CSIRO Mathematical and Informational Sciences Annual Divisional Conference. 2006
LaPointe et al. Mapping gene expression along the anterior-posterior axis of the adult human colon. Digestive Disease Week (AGA). 2006 2005
LaPointe et al. Comparison of classification methodologies to discover biomarkers from gene expression data. Australian Microarrays Conference (AMATA). 2005
Kiiveri et al. Canonical Variate Analysis and Microarrays. Australian Microarrays Conference (AMATA). 2005 LaPointe et al. Comparison of machine learning techniques to identify biomarkers for colorectal cancer in publicly available data. International Society of Computational Biology. 2005 LaPointe et al. Identification of colorectal cancer biomarkers using publicly available gene expression data. Digestive Disease Week (AGA), Chicago. 2005 2004
Young et al. A quantifiable fecal immunochemical test (FIT) for hemoglobin facilitates balancing sensitivity with specificity when screening for colorectal cancer. European Gastroenterology Week. 2004
Smith et al. A quantifiable faecal immunochemical test (FIT) for haemoglobin balancing sensitivity with specificity when screening for colorectal cancer. J. Gastro Hepatology. 19(Suppl): A195, 2004 Smith et al. A quantifiable faecal immunochemical test (FIT) for haemoglobin balancing sensitivity with specificity when screening for colorectal cancer. Gastroenterology. 126(Suppl), 2004 2003
LaPointe et al. Analysis of mRNA expression profiles in colorectal adenomas using k-nearest neighbor cluster analysis. Digestive Disease Week (AGA). 2003
LaPointe et al. Selecting for diagnostic colonoscopy by quantifiable fecal immunochemical tests. Gastroenterology. Supplement to 124(4), 2003 2000
Sinatra et al. Faecal hemoglobin measurement in colorectal neoplasia. J Gastro Hepatology. Supplement to 15, 2000
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